When I upgraded to vCenter 5.1 and being the conscientious IT pro that I am 🙂 I made sure I had good backups for all the relevant bits to restore in case of an emergency. This is not intended to replace a proper backup solution like Veeam Backup and Replication (which is an excellent bit of software which I actually use and highly recommend) but rather as a “belt and braces” supplement.
I have separated vCenter and MSSQL DB servers running on 2 VMs running Windows 2008 R2 (64bit). My DB server is holding the vCenter, SSO (Single Sign On) and VUM (VMware Update Manager) databases. Just to be clear here, this is not the vCenter Appliance.